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Limited data are available with regards to overdosage in human subjects with Entresto. In healthy volunteers, a single dose of Entresto 1200 mg, and 900 mg multiple doses (14 days) have been studied and were well tolerated.
Hypotension is the most likely symptom of overdosage due to the blood pressure lowering effects of Entresto. Symptomatic treatment should be provided.
Entresto is unlikely to be removed by hemodialysis due to high protein binding.
