Euvax-B Dosage/Direction for Use

Euvax-B is for intramuscular use only.
One pediatric dose (neonates, infants, and children aged up to and including 15 years of age) is 0.5 ml containing 10 µg of HBsAg.
One adult dose (from 16 years) is 1.0 ml containing 20 µg of HBsAg.
The immunization regimen consists of three doses of vaccine given according to the following schedule; 1^st dose: at elected date; 2^nd dose: 1 month after the first dose; 3^rd dose: 6 months after the first dose.
Booster vaccination: the WHO does not recommend booster vaccination, as it has been shown that 3 dose series of hepatitis B immunization protects for as long as 15 years, and that a protective anamnestic response occurs after exposure to HBV, even if protective antibodies have been lost over time. However, some local vaccination programmes worldwide currently include a recommendation for a booster dose, and these should be respected.
An alternative 0, 1 and 2 months schedule and a 12 months booster can be used in certain populations (e.g. neonates born from Hepatitis B-infected mothers, someone who has or might have been recently exposed to the virus, certain travelers to high-risk areas).
Additional dose(s) of vaccine may be required in hemodialysis or immunodeficient patients since protective antibody titers (> 10 IU/l) may not be obtained after the primary immunization course.