Combinations contra-indicated: Alpha-1-receptor blockers (see CONTRAINDICATIONS) (prazosin, urapidil, minoxidil): Enhance hypotensive effect. Risk of severe postural hypotension.
Potent CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin, erythromycin and ritonavir since alfuzosin blood levels may be increased (see PHARMACOLOGY UNDER ACTIONS).
Combinations to be taken into consideration: Antihypertensives: Enhance antihypertensive effect and increased risk of postural hypotension (cumulative effect) (see WARNINGS).
Nitrates.