Glaritus Adverse Reactions

The adverse events most commonly associated with human Insulin therapy include the following: Hypoglycemia: Hypoglycemia is the most common adverse effect of Insulin. The incidence of hypoglycemia in regimens that include Insulin Glargine is significantly reduced compared with regimens containing NPH human Insulin. The time of occurrence of hypoglycemia depends on the action profile of the Insulin and may, therefore, change when the treatment regimen is changed.
Oedema: Insulin may cause sodium retention and oedema, particularly if previously poor metabolic control is improved by intensified Insulin therapy.
Hyperglycemia and Ketoacidosis: In patients with Insulin-dependent diabetes, prolonged hyperglycemia can result in diabetic acidosis. If uncorrected, prolonged hyperglycemia or diabetic acidosis can result in loss of consciousness or death. Therefore, it is important that one should obtain medical assistance immediately.
Allergic Reactions: Local Allergy: Patients occasionally experience redness, swelling, and itching at the site of injection of Insulin. This condition called local allergy, usually clears up in a few days to a few weeks. In some instances, this condition may be related to factors other than Insulin, such as irritants in the skin cleansing agent.
Systemic Allergy: Less common, but potentially more serious, is generalized allergy to Insulin, which may cause rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases of generalized allergy may be life threatening.
Injection Site Reactions: As with any Insulin therapy, lipodystrophy may occur at the injection site and delay Insulin absorption. Other injection site reactions with Insulin therapy include redness, pain, itching, hives, swelling and inflammation. Most minor reactions to Insulins usually resolve in a few days to a few weeks.
Insulin resistance: When insulin requirement is increased (>200 IU/day), insulin resistance is said to have developed.
Antibody Production Insulin: Administration may cause the formation of antibodies to insulin. In rare cases, the presence of such insulin antibodies may necessitate adjustment of the insulin dose in order to correct a tendency to hyperglycemia or hypoglycemia.
Other: A marked change in glycaemic control may cause temporary visual impairment, due to temporary alteration in the turgidity and refractive index of the lens. Intensification of Insulin therapy with abrupt improvement in glycaemic control may be associated wtth temporary worsening of diabetic retinopathy.