Hypocalcemia & other bone & mineral metabolism disturbances should be effectively treated before treatment initation. Ensure adequate intake of Ca & vit D. May cause local irritation of the upper GI mucosa. Active upper GI problems (eg, known Barrett's esophagus, dysphagia, other esophageal diseases, gastritis, duodenitis or ulcers). Discontinue use if dysphagia, odynophagia, retrosternal pain or new or worsening heartburn. Development of osteonecrosis of the jaw w/ oral biphosphonates. Concomitant use w/ NSAIDs & oral biphosphonates. CrCl <30 mL/min. Pregnancy & lactation. Childn <18 yr.
Sign Out
