Hypothyroidism; decreased appetite; headache, dysgeusia; HTN, haemorrhage; dyspnoea, cough, dysphonia; diarrhoea, vomiting, nausea, abdominal pain, stomatitis, constipation, dyspepsia; palmar-plantar erythrodysaesthesia (hand-foot syndrome), rash, dry skin; arthralgia, pain in extremity; proteinuria; fatigue, asthaenia, mucosal inflammation; decreased wt. Anaemia; hyperthyroidism; dehydration, hyperkalaemia, hypercalcemia; dizziness; tinnitus; cardiac failure events; venous & arterial embolic & thrombotic events; upper abdominal pain, haemorrhoids, glossodynia; erythema, pruritus, alopecia; myalgia; haematuria; increased lipase, creatinine, ALT, AST, alkaline phosphatase, & amylase.