Alfacalcidol should be administered with extreme caution, if at all, to patients with impaired renal function and with extreme caution in patients with heart disease, renal stones, or arteriosclerosis. Vitamin D analogs should be administered with caution in patients receiving cardiac glycosides, because hypercalcemia in these patients may result in cardiac arrhythmias. Vitamin D analogs should also be used with caution in patients with increased sensitivity to these drugs. Vitamin D analogs should not be administered concurrently, and these drugs should not be administered to patients with hypercalcemia, vitamin D toxicity, or hypersensitivity to the drug or any ingredient in the formulations.
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