Lanzaar Drug Interactions

Metabolism/Transport Effects: Substrate of CYP2C9 (major), CYP3A4 (major);
Inhibits CYP1A2 (weak), CYP2C19 (weak), CYP2C8 (moderate), CYP2C9 (moderate), CYP3A4 (weak).
Avoid Concomitant Use: Avoid concomitant use of losartan with any of the following: pimozide.
Increased Effect/Toxicity: Losartan may increase the levels/effects of: ACE Inhibitors; amifostine; antihypertensives; aripiprazole; carvedilol; cyclosporine (systemic); CYP2C8 substrates; CYP2C9 substrates; hypoglycemic agents; hypotensive agents; lithium; lomitapide; nonsteroidal anti-inflammatory agents; pimozide; potassium-sparing diuretics; rituximab; sodium phosphates.
The levels/effects of losartan may be increased by: alfuzosin; aliskiren; antifungal agents (azole derivatives, systemic); CYP2C9 inhibitors (moderate); CYP2C9 inhibitors (strong); diazoxide; eplerenone; fluconazole; herbs (hypoglycemic properties); herbs (hypotensive properties); MAO inhibitors; mifepristone; milk thistle; pentoxifylline; phosphodiesterase 5 inhibitors; potassium salts; prostacyclin analogues; salicylates; selective serotonin reuptake inhibitors; tolvaptan; trimethoprim.
Decreased Effect: The levels/effects of losartan may be decreased by: CYP2C9 inducers (strong); CYP3A4 inducers (strong); deferasirox; herbs (CYP3A4 inducers); herbs (hypertensive properties); loop diuretics; methylphenidate; nonsteroidal anti-inflammatory agents; peginterferon alfa-2b; rifamycin derivatives; tocilizumab; yohimbine.
Ethanol/Nutrition/Herb interactions: St John's wort may decrease level of losartan.
Some herbal medications may worsen hypertension (eg, licorice); others may increase the antihypertensive effect of losartan (eg, shepherd's purse).
Some herbal medications may increase the hypoglycemic effects of losartan (eg, alfalfa).
Management: Avoid St John's wort; Avoid bayberry; blue cohosh; ginseng (American); kola; licorice; and yohimbine; Avoid black cohosh; California poppy; coleus; golden seal; hawthorn; mistletoe; periwinkle; quinine and shepherd's purse; alfalfa; aloe; bilberry; bitter melon; burdock; celery; damiana; fenugreek; garcinia; garlic; ginger; gymnema; marshmallow; and stinging nettle.