Adult NDMM Patients who are not eligible for transplant In combination w/ dexamethasone: Initially lenalidomide 25 mg once daily on days 1-21 of repeated 28-day cycles w/ dexamethasone 40 mg once daily on days 1, 8, 15 & 22 of repeated 28-day cycles
. In combination w/ bortezomib & dexamethasone: Initially lenalidomide 25 mg once daily on days 1-14 of each 21-day cycle w/ bortezomib 1.3 mg/m
2 SC inj twice wkly on days 1, 4, 8 & 11 of each 21-day & combine w/ dexamethasone until progression. In combination w/ melphalan & prednisone followed by lenalidomide maintenance: Initially lenalidomide 10 mg once daily on days 1-21 of repeated 28-day cycles for up to 9 cycles w/ melphalan 0.18 mg/kg on days 1-4 of repeated 28-day cycles, & w/ prednisone 2 mg/kg on days 1-4 repeated 28-day cycles.
Patients who complete 9 cycles or who are unable to complete the combination therapy due to intolerance 10 mg once daily on days 1-21 of repeated 28-day cycles given until disease progression.
Patients >75 yr In combination w/ dexamethasone: Initially 20 mg once daily on days 1, 8, 15, & 22 of each 28-day treatment cycle.
ASCT Initially 10 mg once daily continuously (on days 1-28 of repeated 28-day cycles) given until disease progression or intolerance. May be increased to 15 mg once daily after 3 cycles of lenalidomide maintenance.
Multiple myeloma w/ at least 1 prior therapy In combination w/ dexamethasone: Initially lenalidomide 25 mg once daily for days 1-21 of repeated 28-day cycles w/ dexamethasone 40 mg once daily on days 1-4, 9-12 & 17-20 each 28-day cycle for the 1st 4 cycles of therapy, & then 40 mg once daily on days 1-4 every 28 days.
ESRD CrCl <30 mL/min (requiring dialysis) 5 mg once daily. On dialysis days, the dose should be administered following dialysis.
Severe renal impairment CrCl <30 mL/min (not requiring dialysis) 7.5 mg once daily; 15 mg every other day.
Moderate renal impairment CrCl 30-50 mL/min 10 mg once daily. May be escalated to 15 mg once daily after 2 cycles if patient is not responding to treatment & is tolerating the treatment.
MDS Initially 10 mg once daily on days 1-21 of repeated 28-day cycles.
ESRD CrCl <30 mL/min (requiring dialysis) Dose should be administered following dialysis. Initially 2.5 mg once daily on days 1-21 of repeated 28-day cycles. Dose level -1: 2.5 mg once daily on days 1-28 of repeated 28-day cycles. Dose level -2: 2.5 mg twice a wk on days 1-28 of repeated 28-day cycles.
Severe renal impairment CrCl <30 mL/min (not requiring dialysis) Initially 2.5 mg once daily on days 1-21 of repeated 28-day cycles. Dose level -1: 2.5 mg every other day on days 1-28 of repeated 28-day cycles. Dose level -2: 2.5 mg twice a wk on days 1-28 of repeated 28-day cycles.
Moderate renal impairment CrCl 30-50 mL/min Initially 5 mg once daily on days 1-21 of repeated 28-day cycles. Dose level -1: 2.5 mg once daily on days 1-28 of repeated 28-day cycles. Dose level -2: 2.5 mg once every other day on days 1-28 of repeated 28-day cycles.
MCL Initially 25 mg once daily for days 1-21 of repeated 28-day cycles.
ESRD CrCl <30 mL/min (requiring dialysis) 5 mg once daily on days 1-21 of repeated 28-day cycles. On dialysis days, administer dose following dialysis.
Severe renal impairment CrCl <30 mL/min (not requiring dialysis) 7.5 mg once daily on days 1-21 of repeated 28-day cycles; 15 mg every other day.
Moderate renal impairment CrCl 30-50 mL/min 10 mg once daily. Dose may be escalated 15 mg once daily after 2 cycles if patient is not responding to treatment & is tolerating the treatment.
FL In combination w/ rituximab: Initially lenalidomide 20 mg once daily for days 1-21 of repeated 28-day cycles for up to 12 cycles of treatment w/ rituximab initially 375 mg/m
2 IV every wk in cycle 1 (days 1, 8, 15, & 22) & day 1 of every 28-day cycle for cycles 2 through 5.
Moderate renal impairment CrCl 30-60 mL/min 10 mg once daily on days 1-21 of repeated 28-day cycles. Dose may be escalated to 15 mg once daily after 2 cycles if patient is not responding to treatment & is tolerating the treatment.