Mild to moderate dysuria and transient decreases in blood pressure are the secondary effects less frequently reported and do not required treatment. Spontaneously reversible and dose dependent elevations in uric acid, lactate dehydrogenase, and alkaline phosphatase occurred during Filgrastim therapy. White blood cell counts of 100,000/mm3 or greater were observed in cancer patients receiving Filgrastim at doses above 3 μg/kg/day. There were no reports of adverse events associated with this degree of leukocytosis.
The incidence of adverse effects associated to chemotherapy: nausea, vomiting, alopecia, diarrhea, anorexia, fever, fatigue, mucositis, headache, constipation, skin rash, cough and thoracic pain are not increased in patients receiving Filgrastim treatment.
There have been rare reports of cutaneous vasculitis in patients treated with Filgrastim. Symptoms of vasculitis generally developed simultaneously with an increase in the absolute neutrophil count.
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