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Pharmacotherapeutic Group Antidiabetic Agent, Sulfonylurea.
Pharmacology: Pharmacodynamics/kinetics: Onset of action: Peak effect: Blood glucose reductions: 2-3 hours.
Duration: 24 hours.
Absorption: 100%; delayed when given with food.
Distribution: Vd: 8.8 L
Protein binding: >99.5%
Metabolism: Hepatic oxidation via CYP2C9 to M1 metabolite (~33% activity of parent compound); further oxidative metabolism to inactivate M2 metabolite.
Half-life elimination: 5-9 hours.
Time to peak, plasma: 2-3 hours.
Excretion: Urine (60%, 80% to 90% as M1 and M2); feces (40%, 70% as M1 and M2).
