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CNS depressants (e.g., ethanol, lorazepam, and oxycodone): Although no pharmacokinetic interactions were seen, additive effects on cognitive and gross motor functioning occurred when pregabalin was coadministered with these drugs. No clinically important effects on respiration were seen.
Angiotensin-converting Enzyme Inhibitors: Increased risk of developing angioedema.
Anticonvulsants: Concomitant administration of gabapentin with pregabalin did not alter pharmacokinetics of gabapentin although the rate, but not the extent, of absorption of pregabalin was decreased slightly.
Antidiabetic Agents: Coadministration of pregabalin and a thiazolidinedione may lead to an additive effect on edema and weight gain and/or fluid retention, possibly exacerbate or leading to heart failure.
