Neuropathic pain Initially 150 mg daily in 2 or 3 divided doses, may be increased to 300 mg daily after 3-7 days interval. Max: 600 mg daily after an additional 7-day interval.
Epilepsy Initially 150 mg daily, may be increased to 300 mg daily after 1 wk. Max: 600 mg daily after an additional wk.
GAD Initially 150 mg daily, may be increased to 300 mg daily after 1 wk, then to 450 mg daily following an additional wk. Max: 600 mg daily after an additional wk.
Fibromyalgia 300-450 mg daily in 2 divided doses; begin at 75 mg bid & may be increased to 150 mg bid w/in 1 wk or may be further increased to 225 mg bid. Max: 600 mg daily after an additional wk.
Renal impairment CrCl ≥60 mL/min Initially 150 mg daily bid or tid. Max dose: 600 mg daily,
≥30 to <60 mL/min Initially 75 mg daily bid or tid. Max dose: 300 mg daily,
≥15 to <30 mL/min 25-50 mg as single daily dose or bid. Max dose: 150 mg daily,
<15 mL/min 25 mg as single daily dose. Max dose: 75 mg daily.
Supplementary dose following haemodialysis Initially 25 mg daily as single dose. Max: 100 mg daily.
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