Liver function test should be monitored. Discontinue immediately if early signs/symptoms of hepatic toxicity or elevated liver enzymes occur.
Use with caution in situations where stimulated gastrointestinal (GI) motility may be dangerous, including mechanical GI obstruction, perforation, or hemorrhage.
If any improvement in gastrointestinal symptoms does not occur after approximately 2 weeks of therapy, this drug should not be continued for a long period.
Use in the Elderly: Use with caution in elderly due to increase risk of adverse effects.