Postmenopausal osteoporosis 0.25 mcg bid. Renal osteodystrophy (dialysis patients) Initially 0.25 mcg daily. Patient w/ normal or slightly reduced serum Ca levels 0.25 mcg every other day. May be increased by 0.25 mcg daily for 2-4 wk intervals if no satisfactory response is observed w/in 2-4 wk. Hypoparathyroidism & rickets Initially 0.25 mcg daily in the morning. May be increased at 2-4 wk intervals if satisfactory response in biochemical parameters & clinical manifestations of disease are not observed.
Chronic hypercalcemia w/ increased serum creatinine. Immobilized patients eg, those who have undergone surgery. Avoid dehydration & maintain adequate fluid intake. Check serum Ca levels every mth. Determine serum Ca & phosphate levels daily during periods of hypercalcemia; serum Ca & creatinine levels at 4 wk, 3 & 6 mth, & at 6 mthly interval thereafter in postmenopausal osteoporosis; serum Ca levels at least twice wkly in hypoparathyroidism & rickets. Possible stimulation of intestinal absorption of phosphate. Avoid other vit D prep. Renal failure (ectopic calcification). Pregnancy. Not to breastfeed during therapy.
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