Present experience concerning overdose with mirtazapine alone indicates that symptoms are usually mild. Depression of the central nervous system with disorientation and prolonged sedation have been reported, together with tachycardia and mild hyper- or hypotension. However, there is a possibility of more serious outcomes (including fatalities) at dosages much higher than therapeutic dose, especially with mixed overdosages. Overdosage is treated with activated charcoal, support of vital functions and symptomatic treatment. Gastric lavage may be considered, if necessary.
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