Momesone Mechanism of Action

Pharmacology: Pharmacodynamics: Mometasone furoate, a synthetic corticosteroid, exhibits anti-inflammatory, antipruritic and vasoconstrictor properties. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates.
Pharmacokinetics: The amount of Mometasone furoate absorbed from the skin depended on the duration of exposure and the surface area which it applied. The concurrent use of occlusive dressings or application to inflamed skin may increase percutaneous absorption of Mometasone furoate. About 0.7% of the drug reportedly reached systemic circulation with normal skin. Following percutaneous penetration Mometasone furoate usually are metabolized in the liver and excreted primarily by the kidneys.