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1. The most serious risks associated with anticoagulant therapy with warfarin are hemorrhage in any tissue or organ and less frequently, necrosis and gangrene of skin and other tissues.
2. Deficiencies of protein C, protein S have been associated with tissue necrosis following warfarin administration.
3. Observe caution when warfarin is administered concomitantly with NSAIDs, including aspirin to be certain that no change in anticoagulation dosage is required.
4. Lower initiation and maintenance doses of warfarin are recommended for elderly patients.
