NOSMEN is contraindicated in: Patients with known hypersensitivity to any component of this product.
Patients with congestive heart failure (NYHA II-IV).
Patients with renal impairment associated with a creatinine clearance < 30 ml/min.
Patients with ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass graft surgery or angioplasty).
Patients with severe hepatic impairment (Child-Pugh score of 10 or more).
Patients with hypertension whose blood pressure has not been adequately controlled.
Patients with active peptic ulceration or gastro-intestinal (GI) bleeding.
Patients with inflammatory bowel disease.
Patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs).
Pregnancy and lactation.
Children under 16 years of age.