Osamine: Each film coated tablet contains Glucosamine sulfate sodium chloride eq. to Glucosamine sulfate 500 mg.
Osamine-S: Each sachet contains Glucosamine Sulfate sodium chloride 1,884 mg eq. to Glucosamine Sulfate 1,500 mg.
Pharmacology: Mechanism of Action: Glucosamine is an endogenous aminomonosaccharide synthesized from glucose and utilized for biosynthesis of glycoproteins and glycosaminoglycans. The sulfate salt of Glucosamine forms half of the disaccharide subunit of keratan sulfate, which is decreased in osteoarthritis, and of hyaluronic acid, which is found in both articular cartilage and synovial fluid. Due to early studies suggesting altered Glucosamine metabolism contributes to development of osteoarthritis.
Pharmacokinetics: Osamine: Absorption: 26%, bioavailability is low due to first-pass hepatic metabolism.
Distribution: Glucosamine is not protein-bound, but rather incorporates into plasma proteins (primarily globulins).
Metabolism: Glucosamine sulfate is rapidly desulfated following oral or parenteral administration; Glucosamine is metabolized (predominantly in the liver) to smaller molecules and ultimately to carbon dioxide, water, and urea.
Excretion: Renal 10%, Feces 11%.
Elimination Half-life: 70 hours.
Osamine: Oral.
Adult dose: 500 mg (1 tablet) 3 times daily for a minimum of 4 weeks or up to 3 years.
Note: Should be preferably taken with meals.
Pediatric dose: Safety and effectiveness have not been established in children.
Osamine-S: 1 sachet once daily for at least 6 weeks.
Hypersensitivity to Glucosamine.
Osamine: Allergy to shellfish.
Osamine: Pregnancy: There is no data on the use of Glucosamine in pregnant women. Glucosamine should only be used during pregnancy if the maternal condition justifies the potential risk to the fetus.
Breastfeeding: Available evidence and/or expert consensus is inconclusive or is inadequate for determining infant risk when used during breastfeeding. Weigh the potential benefits of drug treatment against potential risks before prescribing this drug during breastfeeding.
Osamine: Cardiovascular: Peripheral edema, tachyarrhythmia.
Dermatologic: Erythema, pruritus.
Endocrine/Metabolic: Insulin sensitivity and glucose tolerance.
Gastrointestinal: Nausea, vomiting, dyspepsia, constipation, diarrhea, heartburn, and anorexia.
Neurologic: Drowsiness, headache, insomnia.
Osamine: Major: Theoretical: Doxorubicin, Etoposide, Teniposide.
Moderate: Probable: Warfarin.
Osamine: Store at temperature not more than 30°C.
M01AX05 - glucosamine ; Belongs to the class of other non-steroidal antiinflammatory and antirheumatic products.
Osamine FC tab 500 mg
10 × 10's
Osamine-S powd for oral liqd 1500 mg
30 × 1's
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