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Monotherapy and Combination Therapy: OSENI is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in multiple clinical settings when treatment with both alogliptin and pioglitazone is appropriate (see Pharmacology: Pharmacodynamics: Clinical Studies under Actions).
Important Limitations of Use: OSENI should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis, as it would not be effective in these settings.
Use with caution in patients with liver disease (see Precautions).
