Pebarin Dosage/Direction for Use

Pregabalin is administered in 2 or 3 divided doses. It may be taken with or without food. If Pregabalin is discontinued, dosage should be tapered gradually over at least 1 week.
Epilepsy: The effective dosage of Pregabalin is 150-600 mg daily administered in 2 or 3 divided doses. Therapy is initiated at a dosage of 75 mg twice daily or 50 mg 3 times daily (150 mg daily). Based on individual response and tolerability, dosage may be increased to a maximum of 600 mg daily.
Neuropathic pain: Postherpetic neuralgia: The recommended dosage of Pregabalin is 150-300 mg daily administered in 2 or 3 divided doses. Therapy is initiated at a dosage of 75 mg twice daily or 50 mg 3 times daily (150 mg daily). Dosage may be increased to 300 mg daily within 1 week based on efficacy and tolerability.
Patient who tolerate the drug but do not experience adequate pain relief following 2-4 weeks of treatment with Pregabalin 300 mg daily may receive dosages of up to 600 mg daily administered in 2 or 3 divided doses.
Diabetic peripheral neuropathy: The initial dosage of Pregabalin is 150 mg daily administered in 3 divided doses. The maximum recommended dosage may be increased up to a maximum of 300 mg daily administered in 3 divided doses within 1 week, based on efficacy and tolerability.
Fibromyalgia: The recommended dosage of Pregabalin is 300-450 mg daily. Therapy is initiated at a dosage of 75 mg twice daily (150 mg daily). Dosage may be increased to 300 mg daily (150 mg twice daily) within 1 week based on efficacy and tolerability.
Patients who do not experience adequate benefit with Pregabalin 300 mg daily may have dosage further increased to the maximum recommended dosage of 450 mg daily (225 mg twice daily).
Generalized anxiety disorder: The recommended dosage of Pregabalin is 150-600 mg daily administered in 2 or 3 divided doses. The need for treatment should be reassessed regularly. Therapy is initiated at a dosage of 150 mg daily in 2 or 3 divided doses. Dosage may be increased to 300 mg daily after 1 week based on individual response and tolerability. Following an additional week the dose may be increased to 450 mg per day. The maximum dosage of 600 mg daily may be achieved after an additional week.
Dosage in special populations: Dosage in renal impairment: Pregabalin is mainly excreted by the kidneys. The dosage should be reduced based on creatinine clearance (CrCl) by using the Cockcroft and Gault formula: see Equation.

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In patients with creatinine clearance of less than 60 mL/min, the dosage of Pregabalin should be modified based on creatinine clearance (see table.)

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Hemodialysis: In patient with hemodialysis, the Pregabalin daily dose should be adjusted based on renal function. In addition to the daily dosage adjustment, supplemental dosage should be administered immediately following every 4 hours hemodialysis treatment.
Posthemodialysis supplementary dosage: Patients on the 25 mg single daily dose: Take single supplementary dose of 25 mg or 50 mg.
Patients on the 25-50 mg single daily dose: Take single supplementary dose of 50 mg or 75 mg.
Patients on the 50-75 mg single daily dose: Take single supplementary dose of 75 mg or 100 mg.
Patients on the 75 mg single daily dose: Take single supplementary dose of 100 mg or 150 mg.
Dosage in hepatic impairment: No dosage adjustment is required for patients with hepatic impairment.
Dosage in elderly: Elderly patients may require a dose reduction of Pregabalin due to a decreased renal function.
Dosage in children: There are no adequate and well-controlled studies in children younger than 18 years of age.