Use as an anaesthetic agent.
Hypersensitivity to PENTHROX or any fluorinated anaesthetic.
Known genetic susceptibility to malignant hyperthermia or family history of severe drug reactions to inhaled anaesthetics.
Patients who have a history of showing signs of liver damage after previous methoxyflurane use or halothane anaesthesia.
Clinically significant renal impairment.
Clinically evident cardiovascular instability.
Clinically evident respiratory depression.
Altered level of consciousness.