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Olanzapine is a substrate for cytochrome P-450 (CYP) isoenzyme 1A2. Smoking and administration of drug that induce CYP1A2 such as carbamazepine may cause an increase in Olanzapine clearance. On the other hand, CYP1A2 inhibition of some drug such as fluvoxamine might reduce excretion of Olanzapine.
Caution should be exercised when Olanzapine is administered concomitantly with other centrally acting drug and alcohol. Use of Olanzapine and diazepam or other benzodiazepines that are associated with hypotension may potentiate the orthostatic hypotension associated with Olanzapine.
Concurrent administration of activated charcoal reduced the bioavailability of oral Olanzapine by 50-60% and should be taken at least 2 hours before or after Olanzapine.
