HRT should not be started in the presence of any of the conditions listed as follows. Should any of the conditions appear during HRT use, Progynova should be stopped immediately.
Pregnancy and lactation; undiagnosed vaginal bleeding; known or suspected cancer of the breast; known or suspected premalignant conditions or malignancies, if sex steroid-influenced; presence or history of liver tumors (benign or malignant); severe hepatic disease; active deep venous thrombosis, thromboembolic disorders, or a documented history of these conditions; severe hypertriglyceridemia; and known hypersensitivity to any of the components of Progynova.