Rivoxan Drug Interactions

Rivaroxaban is a substrate of BCRP, CYP2J2 (minor), CYP3A4 (major), P-glycoprotein.
Concurrent use of rivaroxaban and ketoconazole (systemic), clarithromycin, ritonavir, telaprevir, indinavir, lopinavir, idelalisib, conivaptan, cobicistat, darunavir, itraconazole, atazanavir may result in increased rivaroxaban exposure.
Concurrent use of rivaroxaban and rifampin, nevirapine, primidone, carbamazepine, phenytoin, St. John's wort may result in reduced rivaroxaban plasma concentrations.
Concurrent use of rivaroxaban and warfarin, enoxaparin, fondaparinux, acenocoumarol, dalteparin, phenprocoumon, dabigatran etexilate, argatroban, serotonin norepinephrine reuptake inhibitors and SSRIs, lepirudin, heparin, tinzaparin, bivalirudin, Protein C, desirudin, danaparoid, drotrecogin alfa, phenindione, idelalisib, conivaptan may result in an increased risk of bleeding.
Concurrent use of rivaroxaban and oxcarbazepine may result in decreased rivaroxaban efficacy and possible subtherapeutic anticoagulation which could lead to a thrombotic events.