Rybelsus

Semaglutide

Adjunct to diet & exercise to improve glycaemic control in adults w/ type 2 DM.

Initially 3 mg once daily for 1 mth. Maintenance dose: 7 mg once daily for at least 1 mth, may be increased to 14 mg once daily. Max recommended single daily dose: 14 mg.

Should be taken on an empty stomach: Take on an empty stomach at any time of the day then wait at least 30 min before eating/drinking/taking other oral medicinal products. Swallow whole w/ a sip of water. Do not split/crush/chew.

Hypersensitivity. Patients w/ personal or family history of medullary thyroid carcinoma (MTC) or w/ multiple endocrine neoplasia syndrome type 2.

Discontinue use if previous &/or serious hypersensitivity reactions (eg, anaphylaxis, angioedema) occur; pancreatitis is suspected & not to be restarted if confirmed. Not to be used in patients w/ type 1 DM or for diabetic ketoacidosis. Not recommended in patients w/ CHF NYHA class IV. Increased risk of hypoglycaemia; developing diabetic retinopathy complications. Acute pancreatitis. Potential risk of dehydration; MTC & thyroid tumor symptoms (eg, neck mass, dysphagia, dyspnea, persistent hoarseness). History of pancreatitis; angioedema or anaphylaxis w/ another GLP-1 receptor agonist. Patients w/ bariatric surgery. Closely monitor patients w/ diabetic retinopathy. May affect ability to drive & use machines when used w/ sulfonylurea or insulin. Severe renal & hepatic impairment. Not recommended in patients w/ ESRD. Women of childbearing potential should use contraception during treatment. Discontinue at least 2 mth before planned pregnancy. Not to be used during pregnancy & lactation. Childn & adolescents <18 yr. Elderly ≥75 yr.

Hypoglycaemia. Decreased appetite; diabetic retinopathy complications; vomiting, abdominal pain & distension, constipation, dyspepsia, gastritis, GERD, flatulence; fatigue; increased lipase & amylase; dizziness.

Increased AUC of thyroxine & rosuvastatin. Frequent INR monitoring w/ warfarin or other coumarin derivatives.

Antidiabetic Agents

A10BJ06 - semaglutide ; Belongs to the class of glucagon-like peptide-1 (GLP-1) analogues. Used in the treatment of diabetes.

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