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Overdose and treatment: Cimetidine has a large therapeutic window, and no more than minimal toxicity is expected even large overdoses. The total daily dose should not normally exceed 2.4 g. Doses up to 20 g were associated with transient adverse effects similar to those occurring with usual doses. For the treatment of Cimetidine overdosage, the usual measures to remove unabsorbed drug from gastrointestinal tract, clinical monitoring, and supportive therapy should be employed.
Injection: There is no specific antidote for Cimetidine, management of mild to moderate toxicity is symptomatic and supportive treatment. For severe toxicity, intravenous fluids for hypotension, supportive care for CNS depression may be needed.
