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Pharmacology: Pharmacodynamics: Mechanism of Action: Ibuprofen is a non-steroidal anti-inflammatory (NSAID) drug that has demonstrated anti-inflammatory, antipyretic, and analgesic activity by the inhibition of prostaglandin synthesis. Further more ibuprofen reversibly inhibits platelet aggregation.
Pharmacokinetics: Ibuprofen is rapidly and well absorbed from the gastrointestinal tract and extensively bound to plasma proteins (more than 99%). The peak plasma concentrations are reached in 45 minutes after dosing if taken on an empty stomach. When taken with food, peak plasma levels are observed after 1 to 2 hours. The elimination half-life is about 2 hours. It is metabolized in the liver and rapidly excreted in the urine mainly as metabolites (45-80%), their conjugates (14%) and unchanged drug 1%; the remainder is excreted in feces.
