Closely monitor & consider discontinuation or dose reduction if any abnormalities (eg, dizziness, somnolence & loss of consciousness); early symptoms (eg, general malaise, anorexia) are noted. Hepatic function disorder eg, increased AST & ALT. Potential occurrence of obesity; ophth disorders (eg, amblyopia, abnormal & blurred vision, & diplopia). W/drawal symptoms (eg, insomnia, nausea, diarrhea, decreased appetite) w/ abrupt treatment discontinuation. Asian patients. Measure body wt regularly. Gradually reduce dose. Diagnose & treat underlying disease of pain concurrently. Not to operate potentially dangerous machinery (eg, driving car). Women of childbearing potential should use effective contraception. Pregnancy & lactation. Childn. Elderly (reduced renal function & tendency to experience falls).