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Tazocin should not be mixed with other drugs in a syringe or infusion bottle since compatibility has not been established.
Whenever Tazocin is used concurrently with another antibiotic (eg, aminoglycosides), the drugs must be administered separately.
The mixing of beta-lactam antibiotics with aminoglycosides in vitro can result in substantial inactivation of the aminoglycoside. However, amikacin and gentamicin were determined to be compatible with piperacillin/tazobactam in vitro in certain diluents at specific concentrations (see Dosage & Administration).
Because of chemical instability, Tazocin should not be used with solutions containing only sodium bicarbonate.
Lactated Ringer's solution is only compatible with piperacillin/tazobactam EDTA reformulation.
Tazocin should not be added to blood products or albumin hydrolysates.
