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Twynsta

Twynsta

telmisartan + amlodipine

Manufacturer:

Boehringer Ingelheim

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 40/5 mg tab Telmisartan 40 mg, amlodipine besilate 5 mg. Per 80/5 mg tab Telmisartan 80 mg, amlodipine besilate 5 mg. Per 80/10 mg tab Telmisartan 80 mg, amlodipine besilate 10 mg
Dosage/Direction for Use
Adult Initially 40/5 mg, may be titrated up to max 80/10 mg. To be given once daily.
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Overdosage
View Twynsta overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to telmisartan, amlodipine or dihydropyridine derivatives. Biliary obstructive disorders, severe hepatic impairment, cardiogenic shock. Fructose intolerance. Concomitant use w/ aliskiren in patients w/ DM or renal impairment. Pregnancy (2nd & 3rd trimesters). Lactation.
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Warnings
For additional cautionary notes to warn of the potential risk of using the medicine... Click to view Twynsta detailed prescribing information
Special Precautions
Hepatic & renal impairment or recent kidney transplant. Renovascular HTN, intravascular hypovolemia, severe CHF, primary aldosteronism, aortic or mitral valve stenosis, obstructive hypertrophic cardiomyopathy, NYHA III & IV heart failure of non-ischaemic aetiology. Monitor K & creatinine serum levels in patients w/ renal impairment. DM & co-existent CAD. May impair ability to drive or operate machinery. Patients <18 yr.
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Adverse Reactions
Cystitis, depression, anxiety, insomnia, dizziness, somnolence, migraine, headache, paraesthesia, syncope, peripheral neuropathy, hypoaesthesia, dysgeusia, tremor, vertigo, bradycardia, palpitations, hypotension, orthostatic hypotension, flushing, cough, abdominal pain, diarrhoea, nausea, vomiting, gingival hypertrophy, dyspepsia, dry mouth, pruritus, eczema, erythema, rash, arthralgia, muscle spasms, myalgia, back pain, pain in extremity, nocturia, erectile dysfunction, peripheral oedema, asthenia, chest pain, fatigue, oedema, malaise, increased hepatic enzymes & blood uric acid.
Drug Interactions
Other antihypertensives, baclofen, amifostine, alcohol, barbiturates, narcotics, antidepressants may aggravate hypotension or orthostatic hypotension. Systemic corticosteroids may reduce effect. Digoxin, lithium, NSAIDs, CYP3A4 inhibitors or inducers. Simvastatin. Grapefruit juice.
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Storage
View Twynsta storage conditions for details to ensure optimal shelf-life.
Description
View Twynsta description for details of the chemical structure and excipients (inactive components).
Action
View Twynsta mechanism of action for pharmacodynamics and pharmacokinetics details.
MIMS Class
Angiotensin II Antagonists / Calcium Antagonists
ATC Classification
C09DB04 - telmisartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.
Presentation/Packing
Form
Twynsta 40/5 mg tab
Packing/Price
3 × 10's
Form
Twynsta 80/10 mg tab
Packing/Price
3 × 10's
Form
Twynsta 80/5 mg tab
Packing/Price
3 × 10's
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