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Should not take more than necessary.
Vitamin B1: Serious hypersensitivity/anaphylactic reactions can occur.
Vitamin B6: Noted in adults withdrawn from 200 mg/day of pyridoxine.
Vitamin B12: Patients with early Leber disease (hereditary optic nerve atrophy) treated with vitamin B12 suffered severe and swift optic atrophy.
Hypokalemia and sudden death may occur in severe megaloblastic anemia that is treated intensely with vitamin B12.
Dosage of vitamin B12 exceeding 10 mcg/day may produce a hematologic response in patients with folate deficiency.
Blunted or impeded therapeutic response to vitamin B12 may be caused by such conditions as infection, uremia, drugs having bone marrow suppressant properties (eg, chloramphenicol), and concurrent iron or folic acid deficiency.
