Pregnancy: Pregnancy category B.
There are no adequate and well-controlled studies using Acyclovir in pregnant women. The drug should not be administered to pregnant women unless when the potential benefits outweigh the risks to the fetus.
Lactation: Acyclovir is distributed into breast milk and in some instances concentrations are higher than in maternal serum. Caution is advised if Acyclovir is to be administered to a nursing woman. Advise breast-feeding mothers with herpetic lesions near or on the breast to avoid breast-feeding.