May gradually increase iris pigmentation, change eyelashes & vellus hair in the treated eye; eyelid skin darkening. Potential for heterochromia in patients receiving unilateral treatment. Aphakic & pseudophakic patients w/ torn posterior lens cap, or in patients w/ known risk factor for macular edema. Inflammatory neovascular glaucoma; history of herpetic keratitis. Avoid in patients w/ active herpes simplex keratitis & w/ a history of recurrent herpetic keratitis specifically associated w/ prostaglandin analogues. Remove contact lenses before installation due to benzalkonium Cl content. Do not drive or use machines until transient blurring of vision is resolved. Pregnancy & lactation. Childn <1 yr. Pre-term infants (<36 wk gestational age).
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