Xevolac Drug Interactions

Ketorolac may slightly decrease protein binding of warfarin (from 99.5% to 99.3%).
However, because ketorolac can inhibit platelet function, concomitant use with anticoagulants (warfarin, heparin) may increase risk of bleeding complications.
Concomitant use with ACE inhibitors may increase the risk of renal impairment, especially in patients who are hypovolemic.
Concomitant use with diuretics may increase risk of developing renal failure and natriuretic effects may be reduced.
Seizures have been reported rarely with concomitant use of anticonvulsant drugs e.g. phenytoin, carbamazepine.
Hallucinations have been reported with concomitant use of psychoactive drugs e.g. fluoxetine, thiothixene, alprazolam.
Concomitant use with methotrexate has been reported to reduce the clearance of methotrexate and enhancing the toxicity of methotrexate.
Concomitant use with probenecid resulted in decreased clearance and increased plasma level to ketorolac.
NSAIDs appear to decrease renal lithium clearance leading to an increase in plasma lithium concentration, with associated symptoms of lithium toxicity (e.g. nausea, vomiting,neurological effects) have been reported.