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There is insufficient information related to overdosage in humans. The highest doses of trelagliptin administered in clinical trials were single doses of 800 mg to healthy subjects.
In thorough QT/QTc study with single administration of trelagliptin 200 mg or 800 mg in healthy subjects, QT prolongation was observed in the trelagliptin 800 mg group (see Pharmacology: Pharmacodynamics under Actions). Trelagliptin is modestly dialyzable; after 4 hours of hemodialysis, approximately 9.2% of the drug was removed (see Pharmacology: Pharmacokinetics under Actions).
