IV infusion cSSTI Adult & adolescent 12 to <18 yr weighing ≥33 kg 600 mg over 5-60 min every 12 hr for 5-14 days.
CAP All doses given for 5-7 days.
Adolescent 12 to <18 yr weighing <33 kg & childn ≥2 to <12 yr 12 mg/kg over 5-60 min every 8 hr. Max: 400 mg,
≥2 mth to <2 yr 8 mg/kg over 5-60 min every 8 hr,
birth to <2 mth 6 mg/kg over 60 min every 8 hr.
Confirmed or suspected cSSTI caused by S. aureus w/ minimal inhibitory conc (MIC) = 2 or 4 mg/L All doses given over 120 min every 8 hr for 5-14 days.
Adult 600 mg,
adolescent & childn ≥2 to <18 yr 12 mg/kg. Max: 600 mg,
≥2 mth to <2 yr 10 mg/kg.
Confirmed or suspected cSSTI caused by S. aureus w/ MIC <2 mg/L 600 mg over 5-60 min every 12 hr.
Renal impairment cSSTI All doses given over 5-60 min every 12 hr for 5-7 days.
Adult & adolescent 12 to <18 yr weighing ≥33 kg w/ CrCl >30 to ≤50 mL/min 400 mg,
≥15 to ≤30 mL/min 300 mg,
ESRD including haemodialysis 200 mg.
CAP All doses given over 5-60 min every 8 hr for 5-7 days.
Adolescent 12 to <18 yr weighing <33 kg & childn ≥2 to <12 yr w/ CrCl >30 to ≤50 mL/min 8 mg/kg. Max: 300 mg,
≥15 to ≤30 mL/min 6 mg/kg. Max: 200 mg.
Confirmed or suspected cSSTI caused by S. aureus w/ MIC = 2 or 4 mg/L All doses given over 120 min every 8 hr for 5-14 days.
Adult w/ CrCl >30 to ≤50 mL/min 400 mg,
≥15 to ≤30 mL/min 300 mg,
ESRD including haemodialysis 200 mg.
Adolescent & childn ≥2 to <18 yr w/ CrCl >30 to ≤50 mL/min 10 mg/kg. Max: 400 mg,
≥15 to ≤30 mL/min 8 mg/kg. Max: 300 mg.
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