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Hypersensitivity to celecoxib or other ingredients of Zobrex.
Hypersensitivity to sulfonamide.
Patients who have experienced asthma, urticaria, rhinitis, nasal polyps, angioneurotic edema or allergic-type reactions after taking aspirin or other NSAIDs and COX-2 inhibitors.
Children under 18 years, pregnancy especially in the 3rd trimester and lactation.
GI ulceration and bleeding.
Severe hepatic impairment (serum albumin < 25 g/l) or child-pugh score ≥ 10.
Renal impairment with creatinine clearance < 30 ml/min.
Gastroenteritis.
Severe heart failure (NYHA III-IV).
