There is no adequate safety information on Zoledronic acid usage in pregnant women. Studies in pregnant rat show abnormality of fetal organ development. Hence, use Zoledronic acid during pregnancy only if the potential benefit justifies the risk to the mother and fetus.
It is not known whether the drug is excreted in breast milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drugs to the nursing women and possible risks to infants nursing.