Use in pregnancy: There is inadequate evidence of safety in human pregnancy. In animal reproduction studies, adverse effects typical of potent corticosteroids are only seen at high systemic exposure levels; direct intranasal application ensures systemic exposure. However, as with other drugs, the use of Flixonase during human pregnancy requires that the benefits be weighed against the possible risk associated with Flixonase or with any alternative therapy.
Use in lactation: It is not known whether fluticasone propionate is excreted in human breast milk, nor are there any data available from animal studies. However, following intranasal administration to primates, no drug was detected in the plasma, and it is therefore unlikely that the drug would be detectable in milk.