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Antipyrine and cimetidine clinical interaction studies indicate that the co-administration of Arimidex with other drugs is unlikely to result in clinically significant drug interactions mediated by cytochrome P450.
A review of the clinical trial safety database did not reveal evidence of clinically significant interaction in patients treated with Arimidex who also received other commonly prescribed drugs. There were no clinically significant interactions with bisphosphonates (see Pharmacology: Pharmacodynamics under Actions).
Co-administration of tamoxifen or oestrogen-containing therapies with Arimidex should be avoided as this may diminish its pharmacological action (see Contraindications).
