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Concomitant administration with medicinal products that inhibit CYP3A4 (e.g. ritonavir, itraconazole) may inhibit the metabolism of corticosteroids, leading to their increased systemic absorption. The extent to which this interaction is clinically relevant depends on the dose and route of administration of the corticosteroids and on the potency of the CYP3A4 inhibitor.
Due to extensive systemic absorption, neomycin sulphate may increase and prolong respiratory system depression caused by depolarizing muscle relaxants.
Concomitant use of topical neomycin sulphate and systemic aminoglycosides may result in accumulated toxicity.
