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Pharmacology: Pharmacodynamics: Ibuprofen is a propionic acid derivative, having analgesic, anti-inflammatory and antipyretic activity. The drug's therapeutic effects as a non-steroidal anti-inflammatory are thought to inhibit prostaglandin synthetase and therefore the synthesis of prostaglandins which are known to be involved in the sensitisation of pain receptors and the inflammatory process.
Pharmacokinetics: Ibuprofen is rapidly absorbed from the gastrointestinal tract, peak serum concentrations occurring 1-2 hours after administration. Elimination half life is approximately 2 hours.
Ibuprofen is metabolised in the liver to two major inactive metabolites and these together with unchanged ibuprofen are excreted by the kidney either as such or as conjugates. Excretion by the kidney is both rapid and complete. Ibuprofen is extensively bound to plasma proteins.
