Increased dolutegravir plasma conc w/ UGT1A1, UGT1A3, UGT1A9, CYP3A4, &/or P-gp inhibitors. Decreased dolutegravir plasma conc w/ UGT1A1, UGT1A3, UGT1A9, CYP3A4, &/or P-gp inducers. Dolutegravir may increase plasma conc of medicinal products in which excretion is dependent upon OCT2 &/or MATE1 (eg, fampridine/dalfampridine, metformin). Decreased lamivudine AUC & C
max w/ sorbitol or other osmotic acting poly- or monosaccharide alcohols (eg, xylitol, mannitol, lactitol, maltitol). Decreased dolutegravir AUC & C
max w/ Mg/Al-containing antacids; supplements or multivit containing Ca, Fe or Mg (in fasted state). Potential risk of cladribine loss of efficacy. Risk of intracellular interactions w/ emtricitabine.