Eurovastin Special Precautions

Talk to the doctor or pharmacist before taking EUROVASTIN if: There are problems with the kidneys.
There are problems with the liver.
There had been repeated or unexplained muscle aches or pains, a personal or family history of muscle problems, or a previous history of muscle problems when taking other cholesterol-lowering medicines. Tell the doctor immediately if unexplained muscle aches or pains are experienced, especially if feeling unwell or having a fever.
Regularly drinking large amounts of alcohol.
Thyroid gland is not working properly.
Taking other medicines called fibrates to lower the cholesterol. Please read the leaflet carefully, even if other medicines for high cholesterol have been taken before.
Taking medicines used to fight the HIV infection e.g. lopinavir/ritonavir, please see Interactions.
Over 70 (as the doctor needs to choose the right start dose of EUROVASTIN to suit the patient).
There is severe respiratory failure.
The patient is of Asian origin - that is Japanese, Chinese, Filipino, Vietnamese, Korean and Indian. The doctor needs to choose the right start dose of EUROVASTIN to suit the patient.
Taking or have taken in the last 7 days a medicine called fusidic acid (a medicine for bacterial infection) orally or by injection. The combination of fusidic acid and EUROVASTIN can lead to serious muscle problems (rhabdomyolysis).
If any of the previously mentioned applies (or if in doubt), contact the doctor or pharmacist before taking EUROVASTIN.
EUROVASTIN with food and drink: The patient can take EUROVASTIN with or without food.
EUROVASTIN contains lactose: If the patient has an intolerance to some sugars (lactose or milk sugar), contact the doctor before taking EUROVASTIN.
For a full list of ingredients please see Description.
Race: Pharmacokinetic studies have demonstrated an increase in exposure to rosuvastatin in Asian subjects when compared with Caucasians. Initiation of rosuvastatin therapy with 5mg once daily should be considered in Asian patients.
Additional considerations: It is recommended that liver function tests should be performed before the initiation of EUROVASTIN, and thereafter when clinically indicated.
In a small number of people, statins can affect the liver. This is identified by a simple test which looks for increased levels of liver enzymes in the blood. For this reason, the doctor will usually carry out this blood test (liver function test) before and during treatment with EUROVASTIN.
Increases in HbA1c and fasting serum glucose levels have been reported with HMG-CoA reductase inhibitors.
While on this medicine, the doctor will monitor closely the presence of diabetes or risk of developing diabetes. The patient is likely to be at risk of developing diabetes if he/she has high levels of sugars and fats in the blood, is overweight, and has high blood pressure.
In JUPITER study, there was a significantly higher frequency of diabetes mellitus reported in patients taking rosuvastatin (2.8%) versus patients taking placebo (2.3%). Mean HbA1c was significantly increased by 0.1% in rosuvastatin-treated patients compared to placebo-treated patients. The number of patients with HbA1c>6.5% at the end of the trial was significantly higher in rosuvastatin-treated versus placebo-treated patients.
There have been rare post-marketing reports of cognitive impairment (e.g., memory loss, forgetfulness, amnesia, memory impairment, confusion) associated with statin use. These cognitive issues have been reported for all statins. The reports are generally non-serious, and reversible upon statin discontinuation, with variable times to symptom onset (1 day to years) and symptom resolution (median of 3 weeks).
The concomitant use with protease inhibitors is not recommended.
Driving and using machines: Most people can drive a car and operate machinery while taking EUROVASTIN. However, some people feel dizzy during treatment. If feeling dizzy, consult the doctor before attempting to drive or use machines.
Use in Children: If the patient is under 10 years old: EUROVASTIN should not be given to children younger than 10 years.