Holoxan Drug Interactions

Myelotoxicity can be increased as a result of interaction with other cytostatics or radiation. Ifosfamide may intensify skin reactions due to irradiation.
The prior or concurrent administration of nephrotoxic agents like cisplatin, aminoglycosides, acyclovir or amphotericin B may enhance the nephrotoxic effect of ifosfamide and consequently haematotoxic and neurotoxic (CNS) effects as well.
Because of the immunosuppressive effect of ifosfamide, an impaired response to the respective vaccine may occur. Vaccination injury can be caused by live-virus vaccinations.
The concurrent use of ifosfamide may increase the anticoagulant effect of warfarin and thus raise the risk of haemorrhages.
In analogy with cyclophosphamide, the following interactions seem possible: The myelosuppressive action may be enhanced by the concurrent administration of allopurinol or hydrochlorothiazide.
The effect and the toxicity may be enhanced by the concurrent administration of chlorpromazin, triiodothyronine or aldehyde dehydrogenase inhibitors such as disulfiram.
The treatment may increase the hypoglycaemic actions of sulfonylureas.
Prior or concurrent treatment with phenobarbital, phenytoin or chloral hydrate involves the possibility of microsomal liver enzyme induction and thus a faster metabolism of ifosfamide.
The treatment may increase the muscle-relaxant effect of suxamethonium.