Holoxan Special Precautions

The following measures and/or tests are indicated in order to limit or alleviate adverse reactions: Timely administration of antiemetics, regular blood counts, regular checks of renal function parameters, regular check of urinalysis and urinary sediment.
In cases of hepatic or renal impairment before the start of therapy, the use of Holoxan has to be indi­vidually weighed for each patient. It is recommended that patients under Holoxan-therapy are monitored more frequently.
The blood sugar level should be checked regularly in diabetics in order to modify the antidiabetic therapy on time.
It is essential to ensure adequate diuresis.
Fever and/or severe leucopenia require prophylactic administration of antibiotics and/or anti­mycotics.
Attention should be paid to meticulous oral hygiene.
Effects on Ability to Drive and Use Machines: Holoxan may affect a subject's ability to drive a motor vehicle or to operate machinery. This may occur either directly by induced encephalopathy or indirectly as a result of nausea and vomiting, especially when CNS-active drugs or alcohol are taken concomitantly.