L-Stafloxin Dosage/Direction for Use

L-Stafloxin is administered once or twice daily. The dosage depends on the type and severity of the infection and the susceptibility of the presumed causative pathogen.
L-Stafloxin may also be used to complete a course of therapy in patients who have shown improvement during initial treatment with intravenous levofloxacin; given the bioequivalence of the parenteral and oral forms, the same dosage can be used.
Posology: The following dose recommendations can be given for levofloxacin: Dosage in patients with normal renal function (creatinine clearance > 50 ml/min): See Table 1.

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Special populations: Renal impairment (creatinine clearance ≤ 50 ml/min): See Table 2.

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Hepatic impairment: No adjustment of dosage is required since levofloxacin is not metabolised to any relevant extent by the liver and is mainly excreted by the kidneys.
Elderly: No adjustment of dose is required in the elderly, other than that imposed by consideration of renal function.
Paediatric population: Levofloxacin is contraindicated in children and growing adolescents.
Method of administration: For oral use.
L-Stafloxin should be swallowed without crushing and with sufficient amount of liquid. They may be divided at the score line to adapt the dose. The tablets may be taken during meals or between meals. L-Stafloxin should be taken at least two hours before or after iron salts, zinc salts, magnesium- or aluminium-containing antacids, or didanosine (only didanosine formulations with aluminium or magnesium containing buffering agents), and sucralfate administration, since reduction of absorption can occur.