Additive effect on QT interval w/ thioridazine, QTc-prolonging drugs & drugs that decrease electrolyte levels. Increased risk of serotonin syndrome or neuroleptic malignant syndrome w/ MAOIs & other serotonergic drugs (eg, tryptophan, triptans, serotonin reuptake inhibitors, linezolid, lithium, tramadol, fentanyl & its analogues, dextromethorphan, tapentadol, meperidine, methadone, pentazocine or St. John's Wort). Increased risk of bleeding w/ NSAID, aspirin or other anticoagulants. Altered anticoagulant effects of warfarin. Co-administration w/ drug which is also highly bound to protein (eg, warfarin, digoxin) may result in adverse effects due to increased plasma levels of either unbound drug. Increased plasma conc of CYP2D6 substrates w/ a narrow therapeutic index (eg, flecainide, encainide, vinblastine, carbamazepine, TCAs); alprazolam; phenytoin. Reduced efficacy of tamoxifen. Increased/decreased levels of lithium. Adverse reactions including agitation, restlessness & GI distress w/ tryptophan. Prolonged half-life of diazepam. Not recommended w/ alcohol. Elevated blood levels of haloperidol & clozapine.